However, simple clinical data and widely available neurophysiological examinations can truly help to effectively distinguish TEA from TGA.Įpileptic amnesia Focal seizure Temporal lobe epilepsy Transient amnesia Transient global amnesia.Ĭopyright © 2018 Elsevier Inc. Our findings show that in a real-life clinical scenario, TEA is frequent but often overlooked. In the group with TGA, the only imaging alteration found was diffusion weighted imaging (DWI) hippocampal hyperintensity. Finally, structural abnormalities were more frequent in patients with TEA (26.6%). On the contrary, 24-h EEG showed IEAs in all patients with epilepsy, mostly during sleep, suggesting an essential diagnostic role of long-lasting EEG recording for TEA. The analysis of st-EEG results evidenced low sensitivity for interictal epileptiform abnormalities (IEAs) detection (52.3%), with not conclusive data in distinguishing TEA from TGA. This result could be related with a prolonged postictal state in these patients. This study seeks to examine the characteristics of recurrent transient global amnesia, a clinical syndrome characterized by recurrent episodes of anterograde. In our sample, duration of the episodes did not significantly differ between TGA and TEA, even though it is usually described as shorter for TEA. 001) and atypical symptoms such as confusion or language disorder (TGA plus manifestations), appear to be key elements in order to discriminate between TEA and TGA (80% of patients with TEA vs 7.8% of patients with TGA p <. From a clinical point of view recurrence (p <. ![]() Clinical features, neurophysiological, and neuroimaging data were analyzed and compared in the two groups (TEA and TGA).ĭiagnosis of TEA, according to Zeman's criteria, was made in 15 patients (18%). The amnestic attacks are often associated with persistent memory complaints. This diagnosis, however, is seldom suspected by clinicians and remains controversial. Moreover, patients with borderline epileptiform abnormalities on st-EEG or with normal st-EEG but high clinical suspicion for TEA underwent a 16-channel 24-hour ambulatory EEG (24-h EEG). Objective Transient amnesia can be the principal manifestation of epilepsy. All patients underwent neurological evaluation, magnetic resonance imaging (MRI) scan, and standard 21-channel scalp electroencephalography (EEG) recording (standard EEG ). We retrospectively collected clinical data of 83 patients who accessed our emergency ward for an abrupt onset of amnesic disorder, initially interpreted as TGA. We designed this study to evaluate the actual frequency of TEA in a real-life scenario and to highlight the features that can help clinicians distinguishing it from TGA. doi:10.Transient epileptic amnesia (TEA) is an underestimated condition in emergency clinical setting, where most of transient amnesic episodes tend to be classified as transient global amnesia (TGA). Acute-Onset Amnesia: Transient Global Amnesia and Other Causes. What Does Transient Global Amnesia Really Mean? Review of the Literature and Thorough Study of 142 Cases. Quinette P, Guillery-Girard B, Dayan J et al. Transient Global Amnesia: Diffusion-Weighted Imaging Lesions and Cerebrovascular Disease. Optimal Diffusion-Weighted Imaging Protocol for Lesion Detection in Transient Global Amnesia. High-Resolution Diffusion-Weighted Imaging Increases Lesion Detectability in Patients with Transient Global Amnesia. These changes generally appear after symptom resolution, and the highest rate of detection is approximately 2 days after symptom onset 6. These lesions can be bilateral and even multifocal 2-4. Prospective and retrospective studies based on a small number of transient global amnesia patients can detect small punctate regions of abnormally restricted diffusion on DWI/ADC sequences in the CA1 area of the hippocampus (lateral edge of the hippocampal gyrus abutting the temporal horn). Radiographic featuresĬT brain and conventional sequences of MRI brain may show no abnormalities, especially while the patient is symptomatic. ![]() epileptic phenomena, stroke, focal ischemia) have been proposed with no consensus on the exact mechanism 1,6. Most cases show complete resolution of symptoms within a few hours from onset of symptoms 6. ![]() Episodic memories are more-so affected than semantic memories 6. AssociationsĪnterograde and partial retrograde amnesia lasting less than 24 hours without any other neurological or congestive symptoms 6. Transient global amnesia is most common in the 50-70 year age range ref.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |